In the pharmaceutical, nutraceutical, and cosmetic industries, developing new formulations with enhanced functionality, stability, and bioavailability is a complex process that requires a fine balance of expertise and technology. Challenges such as achieving the desired particle size, ensuring excipient compatibility, and maintaining stability during scale-up can significantly delay product development and impact commercial success. Traditional drying methods often lack the precision needed to create complex formulations, resulting in suboptimal product performance. Schedio’s Formulation Development Services are designed to address these challenges, providing a holistic approach to particle engineering and process optimization through Spray Drying and Microencapsulation. Our team of experts supports customers in transforming liquid formulations into stable, high-performance solid forms, enabling rapid product development and efficient scale-up.
With over 300 square meters of dedicated laboratories and specialized equipment, Schedio offers a comprehensive suite of services to support the development of high-value formulations. Each project is approached with a tailored strategy, ensuring that the unique requirements of every formulation are met—from early-stage testing to industrial production.
Spray Drying Services Advanced Particle Engineering Solutions
Spray drying is a highly versatile technique used not only for drying liquid systems but also for engineering particles with precise properties. Our services focus on developing solid amorphous dispersions, microencapsulation of active ingredients, and the creation of functional particles in polymeric or oligosaccharide matrices for taste-masking or controlled release.
Excipient Pre-formulation and Compatibility Tests
- We evaluate the interaction between excipients and active ingredients to identify the optimal formulation matrix.
- This early-stage testing helps ensure that the final product meets both stability and performance criteria.
Lab Scale Spray Drying Tests
- Using dedicated lab-scale spray dryers, we test small batches to develop and refine new formulations.
- During the testing phase, customers can participate in real-time decision-making, allowing for a dynamic and responsive approach to formulation development.
- Each project is documented in a comprehensive report, detailing findings and providing recommendations for further development.
Pilot Scale Spray Drying Tests
- For promising formulations, we conduct larger-scale tests to simulate production conditions.
- This step is crucial for fine-tuning process parameters and preparing the formulation for industrial-scale production.
Scale-Up and Industrialization Support
- Scale-up is a critical stage in formulation development, where processes are adapted from lab scale to industrial scale without compromising product quality.
- Our dedicated spray drying equipment, with an evaporative capacity of up to 5 kg/h, is equipped with two-fluid or rotary nozzles to accurately replicate industrial production conditions.
- This ensures a seamless transition to full-scale production, enabling customers to bring their products to market efficiently.
Microencapsulation Services - Precise Control for Enhanced Product Performance
Microencapsulation is a sophisticated technique used to protect active ingredients, control release rates, and mask undesirable flavors. Our team utilizes multiple microencapsulation methods, each selected and adapted based on the specific technological needs of the project. This flexibility allows us to provide highly tailored solutions for a wide range of applications.
Lab Scale Microencapsulation Testing
- Our laboratory is equipped with specialized systems for small-scale testing and development of microencapsulated formulations.
- Customers receive a detailed plan outlining each stage of the project, allowing for real-time adjustments based on testing outcomes.
- At project completion, we provide a comprehensive report with results and recommendations for optimization.
Pilot Scale Microencapsulation Testing
- For formulations that show potential, we perform pilot-scale microencapsulation to refine the process.
- This stage helps ensure that the encapsulation technique is effective at larger volumes, maintaining the integrity and performance of the active ingredient.
Scale-Up and Industrialization Support
- We offer dedicated facilities and advanced microencapsulation equipment to support the transition from pilot scale to industrial production.
- Our team collaborates closely with customers throughout the process, ensuring that the final product meets all quality and performance specifications.
Analytical and Characterization Services
To ensure the highest standards of quality and performance, Schedio provides a range of analytical services for both spray dried and microencapsulated products. These services are available as part of a complete formulation development project or as standalone offerings for third-party characterization.
Dissolution and Disintegration Testing
- We evaluate the release profile and disintegration behavior of solid dosage forms to ensure optimal performance in vivo.
Residual Moisture Analysis
- Using thermogravimetric analysis (TGA) and Karl Fischer titration, we accurately measure the moisture content of formulations to ensure stability.
Thermal Analysis
- Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) are used to characterize the thermal properties of formulations, providing insights into stability and compatibility.
FTIR and UV-Vis Spectroscopy
- Our advanced spectroscopic techniques are used to analyze the chemical composition and purity of developed products, ensuring compliance with regulatory standards.
At Schedio, we combine cutting-edge technology with deep industry expertise to deliver solutions that help our customers overcome complex formulation challenges and bring innovative products to market faster. Whether you need support for a new formulation or optimization of an existing process, our team is committed to providing the highest level of service and technical excellence.
Technical Info
Find out more about technical detail of our machinery in our brochure
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