Industry estimates indicate that more than 80% of new chemical entities exhibit low solubility, low bioavailability and / or low or inconsistent dissolution rate. Micronization is one of the most utilized solutions for particle size reduction and consequently bioavailability enhancement or drug substance vehiculation to lungs. It is a process that requires a pressurized gas (e.g. compressed air or nitrogen) in order to collide particles against each other. The performances of the machine, strongly vary according to powder properties (flowability, strength, etc.) and it is therefore necessary to be able to adapt the process to each products characteristics.
We take this one step further with our personalized micronization which implies the possibility to completely tailor the process according to powder properties. Schedio Personalized Micronization™ introduces a multitude of parameters, which customers are supported to master in order to meet the expected quality and productivity goals. The new parameters used for jet milling help solve or ameliorate the challenges faced during micronization.
Micronization technologies have revolutionized particle size reduction processes, offering a range of innovative methods to achieve finely-tuned results:
Oval Jet Mill
Featuring an innovative oval-shaped chamber, the Oval Jet Mill enhances the control over jet streams, which in turn facilitates more uniform particle size reduction in a less disruptive manner, to preserve certain structures and characteristics when required by the application.
This capability makes the Oval Jet Mill highly suitable for specialized applications in industries such as pharmaceuticals, where certain particle characteristics can influence drug solubility and absorption.
Spiral Jet Mill
The Spiral Jet Mill employs high-speed gas streams, typically air or nitrogen, to accelerate particles within a spiral flow pattern in the milling chamber. This process causes particles to collide and rub against each other, effectively reducing their size through collision and attrition mechanisms.
The design of the milling chamber, which is independent from the jet mill body, facilitates customization for each product, enhancing the mill's flexibility for multi-product applications. Additionally, the absence of mechanical moving parts within the mill simplifies dismantling, making it a versatile choice for industries like pharmaceuticals and fine chemicals that demand ultra-fine and consistent particle dimensions.
Cryo Milling
Cryo milling is a specialized technique that involves cooling materials to cryogenic temperatures before and during the milling process. By making the materials brittle, they can be fractured more easily with minimal energy.
This method is particularly useful for processing temperature-sensitive or difficult-to-mill materials, as it prevents thermal degradation and preserves the structural integrity of the material. Industries dealing with complex materials like polymers, certain metals, and temperature-sensitive organic compounds benefit from cryo milling's capacity to maintain the quality and functionality of the end product.
Co-axial Jet Mill
The Co-axial Jet Mill marks a significant innovation by integrating a powder injection system that aligns coaxially with the outlet, optimizing the flow and distribution of particles.
This design effectively addresses the inefficiencies and challenges often seen with traditional venturi injectors. The coaxial configuration enhances the mill’s overall efficiency, reducing common drawbacks and improving particle size reduction performance. This mill is particularly advantageous for applications demanding high precision and minimized waste.
Opposed Jet Mill
The Fluidized Bed Opposed Jet Mill operates by using opposing gas jets within a fluidized bed setup, where particles are suspended and subjected to intense jet streams from opposite directions for efficient particle disintegration. This setup facilitates frontal collisions of dry particles, accelerated by pressurized process gas, allowing for micronization to a particle size distribution below 10 microns, depending on the end user's requirements.
The design of this mill ensures a gentle handling process, crucial for materials sensitive to shear forces, and achieves uniform particle distribution. With high automation, this mill is ideal for continuous micronization in applications such as powder production for inhalation, requiring minimal human intervention and ensuring consistent, high-quality outcomes.
These advanced milling technologies are crucial in various sectors, not only for achieving desired material properties but also for enhancing product performance, quality, and consistency across different applications.
Each type of equipment mentioned can be uniquely tailored and optimized to meet the specific requirements of customers, their products, and their processes.
At Schedio we understand the importance of offering flexibility to industries seeking precise outcomes. Whether it's adjusting operational parameters, modifying design features, or fine-tuning processes, these equipment options provide a customizable framework. This ensures that industries can achieve optimal results in terms of particle size distribution, morphology, and overall product functionality. The ability to accommodate individual preferences underscores the commitment to delivering solutions that align perfectly with the diverse needs of each customer and their unique applications.
Technical Info
| LAB LINE | SPIRAL SSM 20 | SPIRAL SSM 44 | ||||
| nominal productivity (Kg/h) | 0,001 min - 0,05 max | 0,01 min - 0,6 max | ||||
| PILOT LINE | SPIRAL SSM 66 | SPIRAL SSM 100 | SPIRAL SSM 150 | OPPOSED SOM 100 | CLASSIFIER SDC 100 | |
| nominal productivity (Kg/h) | 0,05 min - 1 max | 0,25 min - 5 max | 1 min - 15 max | 0,05 min - 5 max | 0,5 min - 5 max | |
| COMPACT COMMERCIAL | SPIRAL SSM 200 | SPIRAL SSM 300 | OPPOSED SOM 300 | CLASSIFIER SDC 300 | ||
| nominal productivity (Kg/h) | 1 min - 30 max | 5 min - 100 max | 5 min - 100 max | 1 min - 100 max | ||
| LARGE COMMERCIAL | SPIRAL SSM 300 | SPIRAL SSM 500 | SPIRAL SSM 600 | OPPOSED SOM 300 | OPPOSED SOM 400 | |
| nominal productivity (Kg/h) | 5 min - 100 max | 10 min - 500 max | 15 min - 700 max | 5 min - 100 max | 8 min - 300 max | |
| INDUSTRIAL | SPIRAL SSM 750 | OPPOSED SOM 600 | ||||
| nominal productivity (Kg/h) | 15 min - 1000 max | 20 min - 750 max |
Direct Line
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