Obtaining Unique Particle Size Distributions, Through Dynamic Classification Applied To Spiral Jet Mills


One of the main challenges facing pharmaceutical companies is achieving unique particle size distributions for their products. This is important for both pharmacokinetic considerations and for raising or circumventing patent barriers. However, traditional micronization methods can make it difficult for formulators to achieve the desired particle size distribution and consistency. It is often not possible to reach the desired particle size distribution only by influencing the two main micronization parameters (federate and pressure).

In this white paper, we will explore how the combination of a spiral jet mill with an in-line dynamic classifier can help overcome these challenges and achieve specific particle size distributions.


The pharmaceutical industry is constantly evolving and facing new challenges. One of the most important aspects of drug development is the micronization process, where the particle size of a drug substance is reduced to improve its bioavailability and efficacy. However, achieving the desired particle size distribution can be a significant challenge for pharmaceutical companies. Unique particle size distributions are crucial for a variety of reasons.

Firstly, the particle size distribution of a drug can greatly impact its pharmacokinetics, which is the study of how a drug is absorbed, distributed, metabolized, and eliminated by the body. A specific particle size range may be necessary for a drug to be effectively absorbed and utilized by the body.

Secondly, the pharmaceutical industry is highly competitive, and achieving a unique particle size distribution can be a way to create or circumvent patent barriers. A unique particle size distribution can be a valuable asset for a company, providing a competitive advantage and protecting their product from generic competitors.

Learn more. Download now the white paper to continue to read.


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