Exploring Spray Drying for Biopharmaceuticals: A Feasible Alternative to Freeze Drying?

Biopharmaceuticals - enzymes, peptides, proteins, vaccines, monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and other advanced therapeutics—have transformed modern medicine. However, their inherent instability presents significant formulation challenges, as factors such as temperature, pH variations, and moisture can compromise their critical quality attributes. Given that most biopharmaceuticals require parenteral administration, they are predominantly formulated as liquid preparations, necessitating strict storage and transportation conditions. But what if there was a way to enhance their stability while maintaining efficacy?

Drying these products into solid forms offers clear advantages for stability and shelf-life extension. While freeze drying remains the standard approach, could spray drying provide a viable alternative? This paper explores the potential of spray drying for biopharmaceuticals, reviewing scientific literature and technological advancements in the field. Particular focus is given to the feasibility of spray drying ADCs, drawing insights from historical applications and recent innovations.

Download the full paper to explore the opportunities and challenges of spray drying in biopharmaceutical manufacturing.