SCHEDIO

Nutraceutical

Nutraceutical solutions that have the right formulations from the right ingredients

If you are in the Nutraceutical industry, you are looking for clean, healthy ingredients that mix well with the proper dosage form and size for the best high quality end product for consumers.

We can help you with new discoveries and developments, along with getting your product to market. Schedio will partner with you to evaluate what is the best way to create your formulations and delivery methods for your product. Our partnership will be from beginning to end, following all safety regulations along the way.

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Milling

The key to a consistent quality in drug formulation relies on homogenized ingredients in terms of particle size.

Milling is one of the most common techniques to help break down large particles to finer ones, which is used for formulations of different drugs.
The pin mill and hammer mill is a mechanical process used for gross milling of large particles greater than 1mm, crushing them into small powder form, usually below 100 microns.

Micronization

Industry estimates indicate that more than 80% of new chemical entities exhibit low solubility, low bioavailability and / or low or inconsistent dissolution rate. Micronization is one of the most utilized solutions for particle size reduction and consequently bioavailability enhancement or drug substance vehiculation to lungs. It is a process that requires a pressurized gas (e.g. compressed air or nitrogen) in order to collide particles against each other. The performances of the machine, strongly vary according to powder properties (flowability, strength, etc.) and it is therefore necessary to be able to adapt the process to each product characteristics.

Classification

A homogeneous particle size distribution is key to a predictable and consistent dissolution profile.  Given a certain particle size distribution, the classifier separates either fine or gross particles from a certain particle size distribution. The process uses the same classification principle of the opposite jet mill.


The dynamic classifier uses the same particle separation principle of the opposite jet mill, to separate particles of significant different particle size distribution. It can be used to separate or remove a portion (either fine or gross) of a certain particle size distribution from the final product. It also helps with removing agglomerates or un-micronizable particles from the final micronized powder.

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